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KMID : 0882420070720050551
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Korean Journal of Medicine
2007 Volume.72 No. 5 p.551 ~ p.557
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A case of pulmonary mucormycosis complicated by pneumomediastinum and subcutaneous emphysema after chemotherapy in a patient with small cell lung cancer
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Lee Seung-Jun
Yoon Seok-Jin
Kim Eun-Jin
Cha Seung-Ick
Park Jae-Yong
Jung Tae-Hoon
Kim Chang-Ho
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Abstract
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Pulmonary mucormycosis is an uncommon fungal opportunistic infection found mainly in immunosuppressed patients
or in patients with poorly controlled diabetes mellitus. A case of pulmonary mucormycosis complicated by
pneumomediastinum and subcutaneous emphysema in small cell lung cancer has not yet been reported to date. A
61-year-old patient with a small cell lung cancer was in a course of clinical improvement with chemotherapy until the
development of new bilateral lung lesions after the fourth round of chemotherapy. After diagnosing mucormycosis by a
transbronchial lung biopsy of the new lesions, the condition of the patient improved with amphotericin B treatment, but
radiographic cavitations of mucormycosis persisted. After 2.4 months of administering oral itraconazole medication,
additional chemotherapy was performed due to cancer progression. Mucormycosis developed complicated by
pneumomediastinum and subcutaneous emphysema, which resulted from fistula formation of the cavity lesion of the left
side into the mediastinum. The patient died of a fungal sepsis despite a surgical resection of the left lesion.(Korean J Med
72:551-557, 2007)
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KEYWORD
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Mucormycosis, Small cell lung cancer, Mediastinal emphysema, Subcutaneous emphysema
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